It will go out to 150 yds +, but unless you get the 20 grain bullet designed for bigger varmints, it may not do the job.
I shot a coyote a couple of years ago with mine at 200 yds and saw the bullet hit, but he ran in circles then ran away across a wheat field that is 2 miles long...he just kept running. Its a really fragile bullet. Close range, I'd use the .17, but at anything longer, the .243 would be the ticket. This is just my opinion.
I shot a coyote with my 17..only about 75 yards and hit him in the ribs...He was still running the last time I saw him..I pretty well use mine on squirrels and rabbits and that's about it...From what I've seen the past bunch of years...I think a coyote is about as tough as a deer when it comes to running off...the last one I shot was with a 300 WSM...it was real effective... ;D ;D
I shot one a few years ago wit a 17 at 90 yards and dropped him then the nxt year I hit one at 110 yards and looked like it never made it stop or slow down. im not a fan of that round I sold mine and just bought a 22-250.